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KMID : 1004820100110040235
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Journal of Biomedical Research
2010 Volume.11 No. 4 p.235 ~ p.242
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Expression Pattern of Phospholipid Hydroperoxide Glutathione Peroxidase mRNA during Mouse Fetal Organ Development
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Jung Ki-Youn
Yon Jung-Min
No Kyong-Ok
Baek In-Jeoung
Lin Chunmei
Jung A-Young
Lee Jong-Geol
Lee Beom-Jun
Yun Young-Won
Nam Sang-Yoon
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Abstract
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Phospholipid hydroperoxide glutathione peroxidase (PHGPx) is a unique antioxidant enzyme involved in reduction of peroxidized phospholipids within biomembranes. To investigate the expression pattern of the PHGPx gene during fetal development, in situ hybridization analyses were performed using mouse FITC-labeled PHGPx cRNA probes in fetal tissues on embryonic days (Ed) 13.5-18.5. During these periods, PHGPx mRNA appeared in the developing telencephalon, diencephalon, spinal cord, and spinal ganglion. In particular, PHGPx mRNA was strongly expressed in pyramidal cells of the cerebral cortex. On Eds 17.5-18.5, PHGPx mRNA was detected in various tissues including liver, intestinal villi and crypt, pancreas, lung, and olfactory epithelium of the nasal cavity. In addition, PHGPx mRNA was highly expressed in the inner ear on Eds 14.5-18.5, brown fat on Ed 17.5, and adrenal gland on Ed 18.5. It is conceivable that PHGPx may act as an important antioxidant against fetal oxidative stress during mouse organogenesis.
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KEYWORD
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Antioxidant, Fetal development, In situ hybridization, PHGPx
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